Fidaxomicin - a promising new drug for Clostridium difficile

I am half way through my 4 week regimen of Vancomycin. I was in to see Nila Suntharam today and this is the latest:


Fidaxomicin, our lead product candidate, is a new antibiotic with a novel mechanism of action being developed for the treatment of Clostridium difficile infection or CDI, the most common nosocomial, or hospital acquired, diarrhea. We believe that Fidaxomicin offers advantages over current treatments due to its demonstrated activity against C. difficile, low rates of recurrence, evidence of low C. difficile resistance, minimal systemic exposure, limited disruption of normally occurring gastrointestinal bacteria and convenient dosing regimen. Our studies indicate that Fidaxomicin acts by inhibiting RNA polymerase, a bacterial enzyme, which results in the death of specific bacteria such as C. difficile. We currently hold rights to fidaxomicin in all regions of the world except for Europe and certain other countries in the Middle East, Africa and the Commonwealth of Independent States, or CIS.

Comment: DIFICID™ (fidaxomicin) is still not available but sounds promising. Meanwhile I will be on Vanco until I am better. Thanks for your prayers!


  1. What determines when flagyl is used or vancomyacin? How long does it take for flagyl to begin to slow or stop diarrhea.

  2. My understanding is that Flagyl is the first choice because it works most times and is much less expensive than Vanco.

    My experience with both (and I have had 5 months of experience) is that once the drugs commence, the D stops in about 4 days. But that doesn't mean one's BM's are "normal".

  3. Flagyl is taken as a bolus and works throughout the accomplished body. Many times women apprehension that the bloom and agog will in fact get worse.

    Sildenafil Citrate


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